Do not confuse this Isaac Alfrey with his first cousin of the same age, the son of Adam Alfrey, who was still living with his parents in 1860 and 1870.

Fleming Co. Ky marriage records list marriage on 30 Sep 1852 of Isaac Alfrey, 21, single, born and resident in Fleming Co., to Lydia Harmon, 16, single, born and resident in Bath Co., Ky.

Isaac and Lydia were first cousins once removed.

1860 census of Bath Co., Ky, Owingsville, lists as :
Alfry, Isaac, 27, farmer; Lydia, 22; Sarah, 7; Albert, 6. All born in Kentucky.

1870 census of Bath Co., Ky, Mudlick precinct, enumerated 24 Aug, lists on p. 41 as family #299/302:
Alfrey, Isaac, 38, blacksmith; Lydia, 35; Sarah, 17; Albert, 15; Henry, 7. All born in Kentucky.

The next household is that of Joseph Myers age 75, with his second wife Mary Bohannon.

1880 census of Bath Co., Ky, White Sulphur precinct, lists on p. 18 as family #156/160:
Alfrey, Isaac, 48, farmer; Liddie, 46, wife; Henry C., 16, son; Cordelia A., 8, dau. All born in Ky.