Morgan Co., Ky marriage records list the marriage on 5 June 1839 of Isaac Brown and Polly Adkins, by L. F. Wilbourn.

1850 census of Morgan Co., Ky, lists as family #705:
Isaac Brown, 26, Va; Mary, 27, Ky; Andrew, 12, Ky; William, 6, Ky; Dulcenia, 4, Ky; George, 2, Ky; Zachariah, 1, Ky.
(I suspect that Isaac and Mary were both really significantly older than listed. They were married in 1839, and the later censuses are consistent with birthdates around 1817/1818 and 1814/1815.)

1860 census of Morgan Co., Ky, district 1, West Liberty P.O., enumerated 19 July, lists on p. 81 as family #498/493:
Isaac, 42, farmer, b. Va; Mary, 44, b. Ky; Andrew, 20; William ,17; Dulcena, 15; Dallas, 11; Zachariah, 9; Moses, 7; Rebeca, 5. All children born in Kentucky.

1870 census of Elliott Co., Martinsburg precinct, lists as family #157:
Brown, Isaac, 53, Va; Mary, 56, Ky; George, 22, Ky; Mosses, 18, Ky; Rebecca, 15, Ky.

1880 census of Elliott Co., Martinsburg precinct, lists as family #276:
Brown, Isaac, 62, Va Va Va; Mary, 70, wife, ditto marks. (Mary was not really born in Virginia, though.)